Injectables, including those with hyaluronic acid, generally last for only a few months. Botox is mostly effective for wrinkles around and above the eyes. Facelifts are pricey and involve major surgery. However, dermal grafting offers a permanent solution for deep facial wrinkles. With this method, dermal tissue is removed from beneath the skin behind the ear and placed under the deep creases via a tiny incision. Since this involves your own tissue, the risk of rejection is minimal.